ABSTRACT
El objetivo de este trabajo fue establecer si la furazolidona utiliza el sistema detoxificante de glutatión en el organismo, mediante la determinación de la cantidad (µmol/ml de sangre) de glutatión total (GT), glutatión oxidado (GSSG), y glutatión reducido (GSH) durante las 5 semanas de vida del pollo de engorda que no consumió aditivos (testigo), comparado con los niveles de GT, GSSG y GSH sanguíneo de las aves que consumieron furazolidona durante las 5 primeras semanas de vida. Hubo diferencia significativa entre el GT (µmol/ml de sangre) y el peso corporal de pollos del grupo testigo y el que consumió furazolidona (55 ppm en el alimento) (R²= -0.709; P< 0.05, y = 2.15 - 0.607x y R²=-0.820 P< 0.05, y = 2.17 -0.61x respectivamente) hubo diferencia significativa (P< 0.05) entre el peso de los pollos del grupo testigo y el de los que consumieron furazolidona (751.3 vs 884.35 g respectivamente)
Subject(s)
Chick Embryo , Poultry/physiology , Poultry/metabolism , Breeding , Breeding/standards , Furazolidone/administration & dosage , Furazolidone/metabolism , Furazolidone/pharmacokinetics , Glutathione/biosynthesis , Glutathione/pharmacokinetics , Glutathione/metabolismABSTRACT
The present work aims at studying the disposition kinetics of single doses of nitrofurantoin [NFT] and furazolidone [FZ] in buffalos of different ages. The experiments were conducted on animals of 6-8 years, 2-12 months and less than 2 months old. The pharmacokinetic analysis of the determined levels of the two tested drugs during 24 hours following their administration has showed age-dependent variations. The rate constant of elimination [Kel] was decreasing with the increase of age with a consequent prolongation of the elimination half life [tB 1/2]. As a net result of the different induced changes in pharmacokinetics, the area under the plasma level curve has been markedly decreased in the young age animals. As a conclusion, dosage regimens of NFT and FZ in buffalo calves should be adjusted according to the age of the animals